Independent Review — Not an Official Store
Independent Analysis
The Hidden Cause of Muscle Loss Over 40
Independent analysis of the myHMB® and DL185™ Dileucine formula gaining attention among people looking to preserve muscle while managing their weight after 40.
90-day money-back guarantee
- Real, US-based company (Norcross, Georgia)
- Two branded, patented ingredients — myHMB® and DL185™
- 90-day money-back guarantee
90
Day Guarantee
- 180
- Capsules per bottle
- 2
- Patented compounds
- 6
- Capsules per serving
- 90
- Day money-back
01 — The Problem
You're Doing the Work. The Results Stopped Showing Up.
The gym sessions haven't changed. The effort hasn't changed. But somewhere after 40, the mirror stopped keeping up — and the stairs started feeling a little longer than they used to.
It isn't laziness and it isn't your imagination. Muscle protein synthesis — the process your body uses to turn training and protein into actual muscle — becomes measurably less efficient as you age. The same workout that built visible strength at 30 returns less at 50.
That's the gap this category of supplement is aimed at. Whether this specific formula closes it is exactly what the rest of this page examines.
02 — Fit Check
Is This Right for You?
Good fit if you…
- Are 40+ and have noticed reduced strength or muscle tone
- Already exercise (or plan to) — the formula is designed to work alongside training and protein intake, not replace them
- Are comfortable with a 90-day trial before judging results
Not a good fit if you…
- Already take a separate Vitamin D or calcium supplement — this formula adds a full 100% DV on top, so add up your total intake
- Expect visible results in days rather than weeks to months
- Are looking for a substitute for resistance training, not a complement to it
03 — How It Works
How It's Meant to Work
Take six capsules daily
One serving per day, as directed on the label. Each bottle holds 180 capsules — a 30-day supply.
Two compounds target the same pathway
DL185™ Dileucine and myHMB® both act on muscle protein synthesis — the first aimed at triggering it, the second at slowing muscle breakdown.
Your training does the actual building
This is a supplement, not a substitute. Resistance training and adequate protein remain the primary drivers; the formula is positioned to support that work, not replace it.
04 — Ingredient Breakdown
What We Know About These Ingredients
Advanced Muscle Plus centers on two branded, patented compounds — DL185™ Dileucine and myHMB® — plus a full daily dose of Vitamin D. Here's honest, general context on each, based on the real label and the vendor's own published claims — not a personal test of this specific product.
DL185™ Dileucine is a newer, patent-protected compound
Dileucine (branded DL185™ by Ingenious Ingredients, LP) is a modified leucine compound marketed as a stronger trigger for muscle protein synthesis than standard leucine or BCAAs. It's real and patented, but also new to market — far less independent, third-party research exists on it than on established ingredients like whey protein or creatine. The 159% protein-synthesis figure and 133-lb leg press gain cited on the official page come from the vendor's own reported study, which we have not independently verified.
myHMB® has more independent research behind it than most branded ingredients
HMB (beta-hydroxy beta-methylbutyrate) is one of the more studied compounds in this category, with human trials — including in older and even bedridden adults — going back over two decades. myHMB® is TSI Group's patented, calcium-bound form of it. The dose here (1,500 mg per serving) is on the lower end of what's typically used in HMB research, which often runs closer to 3 grams a day.
The Vitamin D dose is a full serving, not a token amount
Each serving provides 20 mcg of Vitamin D3 — 100% of the daily value. Vitamin D has a real, studied role in muscle function, and deficiency is common in adults. Some supplements list vitamins in amounts too small to matter just to put them on the label; this one gives the complete recommended daily amount. If you already take a separate Vitamin D supplement, add up your total intake so you don't exceed what you need.
The mTOR framing is real biology, simplified for marketing
mTOR is a real, well-studied pathway involved in muscle protein synthesis, and its activity does change with age. But the official page's claim that it 'stops working' after 40 and gets 'switched back on' by this formula is a simplification — mTOR signaling becomes less efficient with age, it doesn't shut off, and no supplement fully reverses that on its own without training and adequate protein intake.
The customer reviews carry a standard results-vary disclaimer
The official page's testimonials include the standard disclosure that individual results aren't guaranteed and may not reflect a typical outcome. Normal for this product category — worth remembering when reading any specific number (like a stated 40-pound strength increase in one month) in the reviews.
“The mTOR pathway is what tells your body to build muscle from the protein you eat. After 40 it becomes less responsive — which is why the same training returns less than it used to.”
Dr. Greg Eckel, ND, LAc
Licensed naturopathic physician · Former President, Oregon Board of Naturopathic Medical Examiners (governor-appointed)
Dr. Eckel is compensated by Advanced Bionutritionals for endorsing this product. We verified his credentials independently; a paid endorsement is not evidence that the product works.
90-day money-back guarantee
90-Day Money-Back Guarantee — "Build Muscle or It's Free"
05 — What It Costs
Pricing
1 Bottle
30-day supply
$79.95per bottle
$79.95 total
- 90-day money-back guarantee
6 Bottles
180-day supply
$66.65per bottle
$399.90 total
- Free US shipping
- 2 free digital bonuses
- 90-day money-back guarantee
3 Bottles
90-day supply
$71.65per bottle
$214.95 total
- Free US shipping
- 2 free digital bonuses
- 90-day money-back guarantee
90-day money-back guarantee
Advanced Muscle Plus is sold in 1-bottle ($79.95), 3-bottle ($214.95 · $71.65/bottle), or 6-bottle packages ($399.90 · $66.65/bottle). Free US shipping and two digital bonuses apply to the 3- and 6-bottle packages only. Price is set by the official checkout and can change without notice — confirm before you commit.
06 — Before You Buy
Frequently Asked Questions
Is it really possible to build muscle in my 60s or 70s?
Yes — muscle-building capacity declines with age but doesn't disappear. Research on resistance training in older adults, including into their 80s and 90s, consistently shows real strength gains are possible. A supplement can support that process, but training and adequate protein intake remain the biggest levers.
Can I build muscle without hard exercise?
No supplement replaces resistance training for building muscle, including this one. The ingredients here are positioned to support your body's response to training and protein intake, not to substitute for either.
Is Advanced Muscle Plus safe? Are there any side effects?
The label lists Vitamin D (100% DV), myHMB®, and DL185™ Dileucine, plus standard capsule excipients (hydroxypropyl methylcellulose, calcium stearate, silica). If you already take a separate Vitamin D or calcium supplement, add up your total intake. As with any supplement, tell your doctor if you take prescription medication or have a condition affecting calcium or Vitamin D metabolism.
What scientific studies back up the ingredients in Advanced Muscle Plus?
myHMB® has the longer independent research history of the two active ingredients, including trials in older adults. DL185™ Dileucine is newer and patent-protected; the specific performance figures cited on the official page come from the vendor's own reported research, which we have not independently verified. See the ingredient analysis above for more detail.
Do I need a prescription?
No — it's sold as an over-the-counter dietary supplement, not a prescription medication, and it isn't a substitute for prescription treatment of a diagnosed medical condition.
What's the return policy?
The official page states a 90-day money-back guarantee, honored even on empty bottles, through the ABN™ Satisfaction Guarantee. Confirm the exact process (return address, what's covered) on the official checkout before you buy.
Ready to Learn More?
Purchase happens on the official Advanced Bionutritionals checkout, backed by their 90-day guarantee.
90-day money-back guarantee
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This page is for informational purposes only and is not medical advice — talk to your doctor before starting any supplement, especially if you take prescription medication or have a diagnosed condition.